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Biocompatible and biodegradable chitosan/polyvinylpyrrolidone (Chit/PVP) matrices to be used as skin scaffolds for tissue regeneration have been successfully prepared by ionizing radiation processing techniques have been optimized. Results evidence that the structural stability is improved by a more crosslinked network structure which is dependent on PVP content and radiation dose. Radiation, PVP content and N2 bubbling can also be used to tailor the matrices’ surface (porosity/roughness). The evaluation of cell viability showed that HFFF2 cells adhered to the surface of all matrices did not presenting cytotoxicity. In terms of the purposed biomedical application, considering the results of water absorption capacity and degradation behaviour, chitosan/polyvinylpyrrolidone matrices were considered to be very promising to be used as skin scaffold.

 REI 8

Chit/PVP (3%) matrices obtained by gamma irradiation for use as skin scaffolds; (i) dry and swollen state of a matrix obtained with 10 kGy; (ii) degradation behaviour of matrices prepared with 5 and 10 kGy and, (iii) SEM micrographs (surface and cross-section) of the matrix obtained with 10 kGy.


Contact persons:

Helena Casimiro ();

Luís Ferreira ()



Almeida, J.C., Wacha, A.,  Gomes, P.S.,  Alves, LC,  Fernandes, MHV, Margaça, FMA, Salvado, IMM,  Fernandes, MHR, A biocompatible hybrid material with simultaneous calcium and strontium release capability for bone tissue repair, Mater. Science and Eng. C-Materials for Biological Applications, 62 (2016) 429-438, http://dx.doi.org/10.1016/j.msec.2016.01.083

Casimiro, M.H., Gomes, S.R., Rodrigues, G, Leal, J.P., Ferreira, L.M. (2016). Preparation of chitosan/poly vinylpyrrolidone matrices by gamma irradiation: characterization and preliminary cell response studies. IRaP 2016 – 12nd International Symposium on Ionizing Radiation and Polymer, Peninsula de Giens, France, 25-30 September, p. 132.