NANODOSIMETRY AND RADIOBIOLOGICAL STUDIES OF AUGER ELECTRON EMMITERS
The knowledge, skills and competence in nanodosimetry were significantly expanded and strengthened undertaking Monte Carlo simulations using state-of-the-art computer codes to model and simulate the particle tracks and to compute the energy deposition at the nanometric scale and to assess the DNA damage caused by Auger electrons emitted by 99mTc and 125I. The related activities also encompassed experimental studies.
Geometry setup used for MCNP6 Monte Carlo simulations. The 125I isotropic source in this example confirguration is placed at 10.49 Angstrom from the DNA segment centre. Mesh tally values around the decay source represent the intensity of electron fluence.
Deposited energy in the DNA volume, obtained by MC simulations, with the decay sources (125I and 99mTc) at different distances from the DNA center. The green shaded area represents the distance range found by molecular modelling for the compound tested in the experimental studies.
- Edgar Pereira, Letícia do Quental, Elisa Palma, Maria Cristina Oliveira, Filipa Mendes, Paula Raposinho, Isabel Correia, João Lavrado, Salvatore Di Maria, Ana Belchior, Pedro Vaz, Isabel Santos, António Paulo, Evaluation of Acridine Orange Derivatives as DNA-Targeted Radiopharmaceuticals for Auger Therapy: Influence of the Radionuclide and Distance to DNA, Sci. Rep. 7, 42544; doi: 10.1038/srep42544 (2017) (IF=5.22).
- S. Di Maria, A. Belchior, E. Pereira, L. Quental, M.C. Oliveira, F. Mendes, J. Lavrado, A. Paulo, P. Vaz, Dosimetry assessment of DNA damage by Auger-emitting radionuclides: Experimental and Monte Carlo studies, Radiation Physics and Chemistry (2017), http://dx.doi.org/10.1016/j.radphyschem.2017.01.028.