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C2TN

BIOLOGICAL EFFECTS OF BETA- AND/OR AUGER-EMITTING THERAPEUTIC RADIOPHARMACEUTICALS

G2 7

In collaboration with the RS Group, we have been involved in the radiobiological evaluation of Auger-emitting (99mTc) or β emitting (64Cu) radiocompounds, promising candidates for selective and targeted radiotherapy due to the very short range (micrometers to few nanometers) of the emitted βparticles and Auger electrons. Continuing our previous work on the ability of 99mTc-labelled AO-derivatives to cause DNA damage, focusing on late biological effects, an increase on the number of micronuclei (indicative of genetic lesions) induced by 99mTc-containing compounds was observed. In addition, exposure to 99mTc led to the decrease of the cellular survival fraction, indicating the occurrence of a persistent lesion, dependent on the activity of the compound. Studies using the mixed β/Auger emitter 64Cu have also been initiated and have highlighted the ability of this radionuclide to induce both early and late DNA damage in tumoral cells.