Cu-BASED COMPOUNDS AS ANTICANCER TOOLS-TRANSPORT MECHANISMS
Copper metabolism is emerging as an interesting target for imaging or treatment of cancer. Making use of a medically relevant copper radioisotope for cancer theranostics, 64Cu, we are studying the mechanisms of copper transport in different cancer cell lines, by exploiting native cellular copper transport systems. Those include the copper exporters Atp7A and Atp7B, as well as the main copper importer, human copper transporter 1 (hCTR1). These studies are also expected to elucidate the mechanisms behind the increased cellular uptake of a promising new family of cytotoxic bis(thiosemicarbazonato) copper(II) complexes (CuL1-CuL4) recently developed by our group.
More details in
Palma, E. et al. (2017) Biophysical characterization and antineoplastic activity of new bis(thiosemicarbazonato) Cu(II) complexes, J. Inorg. Biochem., 167, 68–79.