MULTIFUNCTIONAL BIOCONJUGATED GOLD NANOPARTICLES FOR CANCER THERANOSTICS
Our goal is to develop target-specific multifunctional gold nanoparticles (AuNPs) for simultaneous delivery of radionuclides and chemotherapeutic agents to cancer cells, while showing radiosensitizing properties. Thus, we have prepared 67Ga-labeled AuNPs stabilized with a thiolated DOTA derivative and functionalized with a bombesin (BBN) analog with promising biological features. Currently, we are studying the cellular internalization and distribution of these BBN-decorated AuNPs aiming to perform microdosimetric studies and assess their radiosensitizing action. We are also studying the coordination of Gd to the nanoconstructs to explore an alternative imaging modality (MRI). Additionally, we are also synthesizing a dithiolated Pt(IV) pro-drug to be incorporated into the AuNP structure to further enhance the anti-cancer activity of the nanoconstruct.
More details in
Silva, F. et al. (2016) Interrogating the Role of Receptor-Mediated Mechanisms: Biological Fate of Peptide-Functionalized Radiolabeled Gold Nanoparticles in Tumor Mice, Bioconjugate Chem., 27, 1153–1164. doi:0.1021/acs.bioconjchem.6b00102.