RADIOLABELED BLOCK COPOLYMER MICELLES FOR IMAGE-GUIDED DELIVERY OF CANCER DRUGS
99mTc-radiolabeled block copolymer micelles (BCMs) loaded with docetaxel (DTX), obtained in high radiochemical yield and purity, were evaluated as potential agents for the simultaneous delivery of radiation/chemotherapy to cancer cells. Studies in different cancer cell lines indicate a cell type and time-dependent uptake. In addition, the DTX-loaded BCMs present higher anti-proliferative activity in comparison to free DTX, which indicates that a similar therapeutic outcome could be achieved with a reduced dose. Biodistribution studies in healthy mice has shown prolonged circulation lifetime in the bloodstream and relevant in vivo stability, important features when considering an effective image-guided DTX delivery system for cancer theranostics.
Contact person: Célia Fernandes
More details in
Ribeiro, E. et al. (2016) Radiolabeled block copolymer micelles for image-guided drug delivery. International Journal of Pharmaceutics, Int. J. Pharm. 515, 692–701. doi: 10.1016/j.ijpharm.2016.11.004.