Tc(I) COMPLEXES WITH L-ARGININE DERIVATIVES FOR TARGETING CATIONIC AMINO ACID TRANSPORTERS
Although relevant from the clinical point of view, radiotracers targeting cationic amino acid transporters are rather unexplored and, in particular, no 99mTc-based molecules are known. The main advantages of using 99mTc, instead of cyclotron-produced radionuclides (e.g. 11C or 18F), relies on the fact that 99mTc is affordable, easily available in many clinics worldwide through generators, and burdens a low dose to patients. Considering our previous work in the design of Tc(I)/Re(I) complexes with pendant L-arginine derivatives for imaging NO/NOS-related tumors, we have prepared novel 99mTc(I)-labeled arginine derivatives that are recognized as substrates by the cationic amino acid transporters, being potentially useful for tumor visualization through targeting of L-arginine-related metabolic pathways
Contact Person: João Correia
See more details in:
Morais, M. et al. (2017) Technetium complexes with L-arginine derivatives for cancer imaging, Dalton Trans., 14537-14547, DOI: 10.1039/C7DT01146F (cover picture).