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C2TN

 
Tc(I) COMPLEXES WITH L-ARGININE DERIVATIVES FOR TARGETING CATIONIC AMINO ACID TRANSPORTERS

GR1 02a

Although relevant from the clinical point of view, radiotracers targeting cationic amino acid transporters are rather unexplored and, in particular, no 99mTc-based molecules are known. The main advantages of using 99mTc, instead of cyclotron-produced radionuclides (e.g. 11C or 18F), relies on the fact that 99mTc is affordable, easily available in many clinics worldwide through generators, and burdens a low dose to patients. Considering our previous work in the design of Tc(I)/Re(I) complexes with pendant L-arginine derivatives for imaging NO/NOS-related tumors, we have prepared novel 99mTc(I)-labeled arginine derivatives that are recognized as substrates by the cationic amino acid transporters, being potentially useful for tumor visualization through targeting of L-arginine-related metabolic pathways

 

Contact Person: João Correia

 

See more details in:

Morais, M. et al. (2017) Technetium complexes with L-arginine derivatives for cancer imaging, Dalton Trans., 14537-14547, DOI: 10.1039/C7DT01146F (cover picture).