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CYSTIC FIBROSIS: NEW MOLECULAR IMAGING TOOLS

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Cystic fibrosis (CF) is the most common lethal autosomic recessive genetic disease among Caucasians. Discovery of the CF gene has improved our understanding of CF pathophysiology and has helped diagnosis. The major goal of this project is to apply a molecular imaging approach to Cystic Fibrosis through the development and biological evaluation of new non-invasive, nuclear-medicine-based probes for CFTR. These novel probes can be then used as imaging biomarkers and transferred as a clinical tool to assess early therapy response in drug evaluation, thereby facilitating translational research. Up to now, we have successfully developed a radioprobe (based on the inhibitor CFTRinh-172a) that has been biologically evaluated for the targeting of CFTR at the plasma membrane of human epithelial cells.

 

Contact Person: Filipa Mendes