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C2TN

64CU-BASED COMPOUNDS FOR CANCER IMAGING AND THERAPY

G1 3

Copper plays a critical role for cancer development and progression, and multiple copper isotopes are explored for cancer imaging and therapy. Studies using the simpler ionic form of the medically relevant copper radioisotope, 64Cu, have been conducted with promising results for prostate cancer theranostics. High levels of 64CuCl2 uptake were observed in prostate cancer cells, with a concomitant increase in DNA damage resulting from exposure to the compound (a work performed in collaboration with the RPS Group). We are currently studying whether this might correlate with the different expression of the native copper cellular transporters exhibited by those cell lines. Continuing our previous work on a family of cytotoxic bis(thiosemicarbazonato) copper(II) complexes (CuL1-CuL4), which presented significant uptake in cancer cells, we have found that such behavior is temperature-dependent, suggesting a predominant active or facilitated uptake of the metal complexes in those cell lines.