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published in the last 5 years 
and other relevant publications
Last 5 years

Filipe Vultos, Célia Fernandes, Filipa Mendes, Fernanda Marques, João D.G.Correia, Isabel Santos, Lurdes Gano (2017) A Multifunctional Radiotheranostic Agent for Dual Targeting of Breast Cancer Cells, ChemMedChem, 12, 1103 –1107, DOI:10.1002/cmdc. 201700 287.

Morais M, Ferreira VFC, Figueira F, Mendes F, Raposinho P, Santos I, Oliveira BL,   Correia JDG (2017), Technetium complexes with L-arginine derivatives for cancer imaging, Dalton Trans. 2017,  14537-14547, DOI: 10.1039/C7DT01146F.

Neves, F. Aires-da-Silva, M. Morais, L. Gano, A. Pinto, S. Aguiar, D. Gaspar, C. Fernandes, João D. G. Correia, M. Castanho (2017), Novel peptides derived from Dengue virus capsid protein translocate reversibly the blood-brain barrier through a receptor-free mechanism, ACS Chem. Biol., 12, 1257−1268. DOI: 10.1021/acschembio.7b00087.

Cantante, C., Lourenço, S., Morais, M., Leandro, J., Gano, L., Silva, N., Leandro, P., Serrano, M., Henriques, A.O., Andre, A., Cunha-Santos, C., Fontes, C., Correia, J.D.G., Aires-da-Silva, F., Goncalves, J., Albumin-binding domain from Streptococcus zooepidemicus protein Zag as a novel strategy to improve the half-life of therapeutic proteins, Journal of Biotechnology (2017) 253:23–33. DOI: 10.1016/j.jbiotec.2017.05.017.

Leticia Quental, Paula, Raposinho, Filipa, Mendes, Isabel Santos, Carmen Navarro-Ranninger, Alvarez-Valdes, Amparo; Huaiyi Huang, Hui, Chao, Riccardo Rubbiani, Gilles Gasser, Adoracion G Quiroga, Antonio Paulo, Combining imaging and anticancer properties with new heterobimetallic Pt(II)/M(I) (M = Re, 99mTc) complexes, Dalton Transactions 2017, 14523-14536, DI:10.1039/c7dt00043j.

Elisa Palma, Filipa Mendes, Goreti Ribeiro Morais, Inês Rodrigues, Isabel Cordeiro Santos, Maria Paula C. Campello, Paula Raposinho, Isabel Correia, Sofia Gama, Dulce Belo, Vítor Alves, Antero J. Abrunhosa, Isabel Santos, António Paulo, Biophysical characterization and antineoplastic activity of new bis(thiosemicarbazonato) Cu(II) complexes, J. Inorg. Biochem. 2017, 167, 68–79.

Edgar Pereira, Letícia do Quental, Elisa Palma, Maria Cristina Oliveira, Filipa Mendes, Paula Raposinho, Isabel Correia, João Lavrado, Salvatore Di Maria, Ana Belchior, Pedro Vaz, Isabel Santos, António Paulo (2017) Evaluation of Acridine Orange Derivatives as DNA-Targeted Radiopharmaceuticals for Auger Therapy: Influence of the Radionuclide and Distance to DNA, Scientific Reports 7, 42544.

In Vivo Performance of a Ruthenium-cyclopentadienyl Compound in an Orthotopic Triple Negative Breast Cancer Model. Mendes N, Tortosa F, Valente A, Marques F, Matos A, Morais TS, Tomaz AI, Gärtner F, Garcia MH. Anticancer Agents Med Chem. 2017;17(1):126-136.



Bihari, Z.; Vultos, F.; Fernandes, C.; Gano, L.; Santos, I.; Correia, J. D.G.; Buglyó, P. (2016) Synthesis, characterization and biological evaluation of a 67Ga-labeled (η6-Tyr)Ru(η5-Cp) peptide complex with the HAV motif. J. Inorg. Biochem., 160, 189–197. doi:10.1016/j.jinorgbio.2016.02.011.

Fernandes, C.; Monteiro, S.; Belchior, A.; Marques, F.; Gano, L.; Correia, J. D. G.; Santos, I. (2016) Novel 188Re multi-functional bone-seeking compounds: synthesis, biological and radiotoxic effects in metastatic breast cancer cells. Nucl. Med. Biol. 43, 150–157. doi:10.1016/j.nucmedbio.2015.11.004.

Gama, S.; Rodrigues, I.; Mendes, F.; Santos, I. C.; Gabano, E.; Klejevskaja, B.; Gonzalez-Garcia, J.; Ravera, M.; Vilar, R.; Paulo, A. (2016). Anthracene-Terpyridine Metal complexes as new G-Quadruplex DNA binders. J. Inorg. Biochem, 160, 275–286. doi:10.1016/j.jinorgbio.2016.04.002

Silva, F.; Zambre, Ajit; Campello, M. P. C.; Gano, L.; Santos, I.; Ferraria, A. M.; Ferreira, M. J.; Singh, A.; Upendran, A.; Paulo ,A.; Kannan, R. (2016) Interrogating the Role of Receptor-Mediated Mechanisms: Biological Fate of Peptide-Functionalized Radiolabeled Gold Nanoparticles in Tumor Mice, Bioconjugate Chem., 27, 1153–1164. doi:0.1021/acs.bioconjchem.6b00102.

Oliveira, M. C.; Gano, L.; Santos, I.; Correia, J. D. G., Serrano, I. D.; Santos, S. S.; Ribeiro, M., Perazzo, J., Tavares, I.; Montserrat, H.; Bardaji, E.; Castanho, M. A. (2016) Improvement of the pharmacological properties of amidated kyotorphin by means of iodination, MedChemComm, 7, 906-913. doi:10.1039/C6MD00028B.

Ševčík, R.; Vaněk, J.; Michalicová, R.; Lubal, P.; Hermann, P.; Santos, I. C.; Santos, I; Campello, M. P. C. (2016) Formation and decomplexation kinetics of copper(II) complexes with cyclen derivatives having mixed carboxylate and phosphonate pendant arms, Dalton Trans., 45, 12723–12733. doi:10.1039/c6dt01127f.

Ribeiro, E.; Alho, I.; Marques, F. Gano ,L.; Correia, I.; Correia, J. D.G.; Casimiro, S.; Costa, L.; Santos, I.; Fernandes, C. (2016) Radiolabeled block copolymer micelles for image-guided drug delivery. International Journal of Pharmaceutics, Int. J. Pharm. 515 (2016) 692–701. doi: 10.1016/j.ijpharm.2016.11.004.

Melo, R., Fieldhouse, R., Melo, A., Correia, J.D.G., Cordeiro, M.N.D.S., Gumus, Z. H., Costa, J., Bonvin, A.M.J.J., Moreira, I. S. (2016) A Machine Learning Approach for Hot-Spot Detection at Protein-Protein Interfaces, International Journal of Molecular Sciences, 17, E1215, doi: 10.3390/ijms17081215



Oliveira, B. L.; Morais, M.; Mendes, F.; Moreira, I. S.; Cordeiro, C; Fernandes, P. A.; Ramos, M. J.; Alberto, R.; Santos, I.; Correia, J. D. G. (2015). Re(I) and Tc(I) complexes for targeting nitric oxide synthase: Influence of the chelator in the affinity for the enzyme. Chem. Biol. Drug Des., 86, 1072-86. doi:10.1111/cbdd.12575.

Nunes, P.; Morais, G.R.; Palma, E.; Silva, F.; Oliveira, M.C.; Ferreira, V.F.C.; Mendes, F.; Gano, L.; Miranda, H.V.; Outeiro, T.F.; Santos, I.; Paulo, A. (2015). Isostructural Re(I)/99mTc(I) Tricarbonyl Complexes Functionalized with Benzothiazole Derivatives for Cancer Theranostics. Org. Biomol. Chem., 13, 5182-5194. doi: 10.1039/C5OB00124B.

Silva, F.; Campello, M. P. C.; Gano, L.; Fernandes, C.; Santos, I. C.; Santos, I.; Ascenso J. R., Ferreira, M. J.; Paulo A. (2015). Chemical, radiochemical and biological studies of new gallium(III) complexes with hexadentate chelators. Dalton Transactions, 44, 3342–3355. doi: 10.1039/C4DT02274B.

Vultos, F.; Cunha, S.; Fernandes, C.; Oliveira, M. C.; Marques, F.; Botelho, M. F.; Santos, I.; Gano, L. (2015) New estradiol based 111In complex towards the estrogen receptor. Radiochimica Acta, 103, 765-776. doi: 10.1515/ract-2014-2355.



Synthesis and characterization of functional multicomponent nanosized gallium chelated gold crystals", A. Zambre, F. Silva, A. Upendran, Z. Afrasiabi, Y. Xin, A. Paulo, R. Kannan, Chem. Commun., 2014, 50, 3281-3284.

Re(I) and 99mTc(I) tricarbonyl complexes with ether-containing pyrazolyl-based chelators: Chemistry, biodistribution and metabolism”, C. Fernandes, L. Maria, L. Gano, I. C. Santos, I. Santos, A. Paulo, J. Organomet. Chem., 2014, 760:138-148.

da Silva AF, Seixas RS, Silva AM, Coimbra J, Fernandes AC, Santos JP, Matos A, Rino J, Santos I, Marques F., “Synthesis, characterization and biological evaluation of carboranylmethylbenzo[b]acridones as novel agents for boron neutron capture therapy”, Org Biomol Chem 2014, 12:5201-11.

Morais, M. P. C. Campello, C. Xavier, J. Heemskerk, J. D. G. Correia, T. Lahoutte, V. Caveliers, S. Hernot, I. Santos,Radiolabeled mannosylated dextran derivatives bearing an NIR-fluorophore for sentinel lymph node imaging”, Bioconjugate Chem. 2014, 25, 1963 – 1970.

Biological assessment of novel bisphosphonate-containing 99mTc/Re-organometallic complexes”, C. Fernandes, S. Monteiro, P. Mendes,  L. Gano, F. Marques, S. Casimiro, L. Costa, J. D. G. Correia, I. Santos, J. Organomet. Chem. 2014, 760, 197 – 204.

“A 99mTc(CO)3-labeled benzylguanidine with persistent heart uptake”, B. L. Oliveira, M. Morais, L. Gano, I. Santos, J. D. G. Correia, J. Labelled Cmpd. Rad. 2014, 57, 358-364.

“Biodistribution of a 67Ga-labeled anti-TNF VHH single-domain antibody containing a bacterial albumin-binding domain (Zag)” M. Morais, C. Cantante, L. Gano, I. Santos, S. Lourenço, C. Santos, C. Fontes, F. Aires da Silva, J. Gonçalves, J. D.G. Correia, Nucl. Med. Biol. 2014, Suppl., 41, e44-e48.

"Novel Heterobimetallic Radio-Theranostic: Preparation, Activity, and Biodistribution", L. Adriaenssens, Q. Liu, F. Chaux-Picquet, S. Tasan, M. Picquet, F. Denat, P. Le Gendre, F. Marques, C. Fernandes, F. Mendes, L. Gano,MPC. Campello, E. Bodio, Chem Med Chem 9:1567-1573, 2014.



Influence of the bifunctional chelator on the pharmacokinetic properties of 99mTc(CO)3-abeled cyclic α-melanocyte stimulating hormone analog, Morais M, Oliveira BL, Correia JD, Oliveira MC, Jiménez MA, Santos I, Raposinho PD., J Med Chem. 2013 Mar 14;56(5):1961-73. doi: 10.1021/jm301647t.

Mono- and dicationic Re(I)/99mTc(I) tricarbonyl complexes for the targeting of energized mitochondria, Moura, C., Mendes, F., Gano, L., Santos, I., & Paulo, A. (2013), Journal of Inorganic Biochemistry, 123, 34-45. DOI: 10.1016/j.jinorgbio.2013.02.008.

Insights into the structural determinants for selective inhibition of nitric oxide synthase isoforms, Oliveira, B.L., Moreira, I.S., Fernandes, P.A., Ramos, M.J., Santos, I., & Correia, J.D.G. (2013). Journal of Molecular Modeling, 19(4), 1537-1551. DOI: 10.1007/s00894-012-1677-8.

Radiosynthesis and in vivo Evaluation of a 18F-Labelled Styryl-Benzoxazole Derivative for beta-Amyloid Targeting, Ribeiro Morais G, Kniess T, Bergmann R, Gano L, Abrunhosa A, Santos I, Paulo A, Appl Rad Isotopes, 82, 100-104 (2013) doi: 10.1016/j.apradiso.2013.07.003.



Other Relevant Publications

Carina Neto, Maria Cristina Oliveira, LurdesGanoa, FernandaMarquesa, Takumi Yasuda, ThiesThiemann, Torsten Kniess, Isabel Santos, Novel 7α-alkoxy-17α-(4′-halophenylethynyl)estradiols as potential SPECT/PET imaging agents for estrogen receptor expressing tumours: Synthesis and binding affinity evaluation, Steroids 2012, 77 (11), 1123-1132.

Maurício Morais, Paula D. Raposinho, Maria Cristina Oliveira, David Pantoja-Uceda, Maria Angeles Jiménez, Isabel Santos, and João D. G. Correia, Organometallics, 2012, 31 (16), pp 5929–5939

Carolina Moura, Lurdes Gano, Filipa Mendes, Paula D.Raposinho, A.M.Abrantes, M.F.Botelho, IsabelSantos, AntónioPaulo, 99mTc(I)/Re(I) tricarbonyl complexes for in vivo targeting of melanotic melanoma: Synthesis and biological evaluation, Eur. J. Med. Chem., 2012, 50, 350-360.

Filipa Mendes, Lurdes Gano, Célia Fernandes, António Paulo, Isabel Santos, Studies of the myocardial uptake and excretion mechanisms of a novel 99mTc heart perfusion agent, Nucl. Med. Biol., 2012, 39, 207-213.

Carina Neto, Célia Fernandes, Maria Cristina Oliveira, Lurdes Gano, Filipa Mendes, Torsten Kniess, Isabel Santos, Radiohalogenated 4-anilinoquinazoline-based EGFR-TK inhibitors as potential cancer imaging agentes, Nucl. Med. Biol., 2012, 39, 247-260 .

Morais, GR; Vicente Miranda, H; Santos, IC; Santos, I; Outeiro, TF; Paulo, A, Synthesis and in vitro evaluation of fluorinated styryl benzazoles as amyloid-probes, BIOORGANIC & MEDICINAL CHEMISTRY, 2011, 19, 7698-7710.

Esteves, T; Marques, F; Paulo, A; Rino, J; Nanda, P; Smith, CJ; Santos, I, Nuclear targeting with cell-specific multifunctional tricarbonyl M(I) (M is Re, Tc-99m) complexes: synthesis, characterization, and cell studies, JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY, 2011, 16 1141-1153.

Mannosylated Dextran Derivatives Labeled with fac-[M(CO)(3)](+) (M=Tc-99m, Re) for Specific Targeting of Sentinel Lymph Node, Morais, M; Subramanian, S; Pandey, U; Samuel, G; Venkatesh, M; Martins, M; Pereira, S; Correia, JDG; Santos, I, MOLECULAR PHARMACEUTICS , 2011, 8, 609-620.

Tc-99m(CO)(3)-labeled pamidronate and alendronate for bone imaging, Palma, E; Correia, JDG ; Oliveira, BL; Gano, L; Santos, IC; Santos, I, DALTON TRANSACTIONS, 2011, 2787-2796.

Re and Tc Tricarbonyl Complexes: From the Suppression of NO Biosynthesis in Macrophages to in Vivo Targeting of Inducible Nitric Oxide Synthase, Oliveira, BL; Raposinho, PD; Mendes, F; Figueira, F; Santos, I; Ferreira, A; Cordeiro, C; Freire, AP; Correia, JDG, BIOCONJUGATE CHEMISTRY, 2010, 21, 2168-2172.

Synthesis, characterization and biological evaluation of In(III) complexes anchored by DOTA-like chelators bearing a quinazoline moiety,Garcia; Kubicek, V; Drahos, B; Gano, L; Santos, IC; Campello, P; Paulo, A; Toth, E; Santos, I, METALLOMICS, 2010, 8, 571-580.

A quinazoline-derivative DOTA-type gallium(III) complex for targeting epidermal growth factor receptors: synthesis, characterisation and biological studies, Garcia, R ; Fouskova, P; Gano, L; Paulo, A; Campello, P; Toth, E; Santos, I, JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY , 2009, 2, 261-271.

Re and Tc-99m organometallic complexes containing pendant L-arginine derivatives as potential probes of inducible nitric oxide synthase, Oliveira, BL; Correia, JDG; Raposinho, PD; Santos, I; Ferreira, A; Cordeiro, C; Freire, AP, DALTON TRANSACTIONS, 2009, 152-162.

Tris(pyrazolyl)methane Tc-99m tricarbonyl complexes for myocardial imaging, Maria, L; Fernandes, C; Garcia, R; Gano, L; Paulo, A; Santos, IC; Santos, I, DALTON TRANSACTIONS, 2009, 603-606.

Chemical and biological evaluation of Sm-153 and Ho-166 complexes of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrakis(methylphosphonic acid monoethylester) (H(4)dotp(OEt)), Forsterova, Michaela; Jandurova, Zuzana; Marques, Fernanda; et al. JOURNAL OF INORGANIC BIOCHEMISTRY, 2008, 102, 1531-1540.

Melanoma targeting with alpha-melanocyte stimulating hormone analogs labeled with fac-[Tc-99m(CO)(3)](+): effect of cyclization on tumor-seeking properties, Raposinho, PD; Xavier, C; Correia, JDG; Falcao, S; Gomes, P; Santos, I, JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY 2008, 449-459.

Rhenium and technetium complexes bearing quinazoline derivatives: progress towards a (99m)Tc biomarker for EGFR-TK imaging, Fernandes, C; Santos, IC; Santos, I; Pietzsch, HJ; Kunstler, JU; Kraus, W; Rey, A; Margaritis, N; Bourkoula, A; Chiotellis, A; Paravatou-Pestsotas, M ; Pirmettis, I, DALTON TRANSACTIONS, 2008, 3215-3225.

Radioiodination of new EGFR inhibitors as potential SPECT agents for molecular imaging of breast cancer, Fernandes, C; Oliveira, C; Gano, L; Bourkoula, A; Pirmettis, I; Santos, I, BIOORGANIC & MEDICINAL CHEMISTRY, 2007, 15, 3974-3980.

Very small and soft scorpionates: Water stable technetium tricarbonyl complexes combining a bis-agostic (k(3)-H, H, S) binding motif with pendant and integrated bioactive molecules, Maria, L; Paulo, A; Santos, IC; Santos, I; Kurz, P; Spingler, B; Alberto, R, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 2006, 128, 14590-14598.