Laboratories for Chemical Synthesis and for Solution Thermodynamic Studies
The facilities include three independent laboratories (SQ1, SQ2 and SQ3) dedicated to the synthesis of novel non-radioactive molecules to be applied in the development of molecular/nanosized tools for application in nuclear imaging (PET or SPECT) or radionuclide therapy, namely for cancer theranostics. The research activities developed in these facilities are focused on the synthesis of organic compounds and inorganic or organometallic complexes of d- and f- transition elements. Organic compounds include biologically active molecules (e.g. peptides) and bifunctional chelators, with or without biologically active fragments, to prepare complexes with non-radioactive d- and f- transition metals. The synthesized compounds can be characterized by multinuclear NMR spectroscopy, X-ray crystallography, mass spectrometry and RP-HPLC, amongst other techniques. The thermodynamic behaviour of some of the chelators and related metal complexes in solution can be studied by potentiometry in the Laboratory for Solution Thermodynamic Studies.
Main equipment:
- Vacuum lines
- Rotary Evaporators
- Analytical RP-HPLC
- Lyophilizer
- CORIO CD-200F refrigerated circulator (Julabo GmbH)
- Potentiometric system Orion Star T910 pH Titrator (Thermo Scientific™)
Contacts:
SQ1 – Ana Sofia Gama – sofia.gama@ctn.tecnico.ulisboa.pt
SQ2 – Célia Fernandes – celiaf@ctn.tecnico.ulisboa.pt
SQ3 – João Galamba Correia – jgalamba@ctn.tecnico.ulisboa.pt