Radiopharmaceutical Sciences and Health Physics
C2TN research activities organized under an integrative program devoted to Health and Life Sciences intend, in the long term, to reduce the negative impact of diseases associated with aging and non-communicable diseases, under the framework of Objective 3 of the UN 2030 Sustainable Development Agenda, more specifically to reduce premature mortality through prevention and treatment. Within that context, the Radiopharmaceutical Sciences and Health Physics (RSHP) thematic strand is focused on the application of ionizing radiation in different aspects of Human Health, tackling two major research topics: Theranostics and Personalized Medicine, and Medical Physics.
RADIOPHARMACEUTICAL SCIENCES
BIOLOGICAL EFFECTS OF IONIZING RADIATION AND METROLOGY
RADIATION PROTECTION AND DOSIMETRY
RADIOPHARMACEUTICAL SCIENCES
- Development and pre-clinical evaluation of targeted radiopharmaceutical for imaging or theranostic applications, including multimodal systems (e.g. combining SPECT/PET imaging with optical imaging or MRI).
- Collaborative research with academic and industrial partners involved on drug development, using nuclear imaging and animal models of disease, as well as molecular modelling and computational tools for a more rational drug design.
BIOLOGICAL EFFECTS OF IONIZING RADIATION AND METROLOGY
- Evaluation of the biological effects of ionizing radiation at the molecular (e.g. DNA repair systems) and cellular levels (e.g. radiomicrobiology), in combination with radioprotective or radiosensitizer agents.
- Computational and modelling studies in micro- and nanodosimetry of external and targeted radiotherapy.
RADIATION PROTECTION AND DOSIMETRY
- Quantification of the risks associated to radiation exposure, including low dose and protracted exposures.
- Dosimetry of ionizing radiation in medical applications for new and emerging diagnostic and therapeutic techniques by combining clinical data, biokinetic models and Monte Carlo simulations using voxel phantoms.
Thematic strand leader
- Filipa Mendes
Objective managers
Biological Effects of Radiation and Medical Dosimetry
- Ana Belchior
Radioactive Tools for Molecular Imaging and Theranostics
- Sofia Gama
Pre-clinical Evaluation and Imaging
- Bruno Oliveira